Platelet-Vessel Wall Interactions
نویسندگان
چکیده
منابع مشابه
Systems biology of platelet-vessel wall interactions
Blood systems biology seeks to quantify outside-in signaling as platelets respond to numerous external stimuli, typically under flow conditions. Platelets can activate via GPVI collagen receptor and numerous G-protein coupled receptors (GPCRs) responsive to ADP, thromboxane, thrombin, and prostacyclin. A bottom-up ODE approach allowed prediction of platelet calcium and phosphoinositides followi...
متن کاملPlatelet-vessel wall interactions in atherosclerotic disease.
During the prolonged course of atherosclerotic disease, platelets are of central importance as they contribute to the initiation of the disease, to its progression and acute exacerbation but also provide potential regenerative mechanisms. Platelets secrete chemokines and cytokines that mediate vascular inflammation and are in turn activated by substances released from cells of the vascular wall...
متن کاملPlatelet and von Willebrand factor interactions at the vessel wall.
The process of platelet thrombus formation contributes to the haemostatic response that prevents excessive blood loss after tissue injury, but may become a life-threatening disease mechanism by causing the acute thrombotic occlusion of atherosclerotic arteries. The participation of platelets in the formation of thrombi is centered on their adhesive properties and the ability to respond to stimu...
متن کاملThe vessel wall and its interactions.
Blood cell interactions with the vessel wall were first documented almost 170 years ago. Modern advances have revealed that leukocyte and platelet interactions with the endothelium are at the nexus of complex, dynamic cellular and molecular networks that, when dysregulated, may lead to pathological inflammation and thrombosis, which are major sources of morbidity and mortality in the Western wo...
متن کاملCyclooxygenase isoforms and platelet vessel wall interactions in the apolipoprotein E knockout mouse model of atherosclerosis.
BACKGROUND Cyclooxygenase (COX) activity is induced in human atherosclerosis, and the products formed may modify the disease directly or through an effect on platelets. We examined the role of COX-1 and -2 on platelet vessel wall interactions and development of atherosclerosis in a murine model. METHODS AND RESULTS Apolipoprotein E-deficient (apoE-/-) mice fed a 1% cholesterol diet were treat...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1988
ISSN: 0021-9746
DOI: 10.1136/jcp.41.9.1030-c